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目的:验证和进一步确定黄金菊解热的药效组分,为建立与其临床疗效对应的质量标准提供科学依据。方法:在HPLC分析法确定初步药效组分基础上,采用大鼠的酵母致热实验,对发热模型进行连续10 h的体温检测,设立了黄金菊水煎剂组、药效组分的低中高剂量组、阳性组与模型组进行比较,同时选用同类病症常用药双黄连口服液进行同步对照。结果:空白组与模型组相比,统计学差异显著(P<0.01),用药各组与模型组相比,差异有统计学意义(P<0.05),黄金菊的低、中、高药效组分组的大鼠体温在2～6 h的发热期内均低于模型组体温,具有明显的解热作用。结论:黄金菊的药效组分(黄芩苷、绿原酸、荭草苷和牡荆苷)可以作为黄金菊的解热药效组分。
Objective: To verify and further determine the anti-pyrethrum medicinal components, in order to establish the quality standards corresponding to its clinical efficacy to provide a scientific basis. Methods: On the basis of determining the preliminary pharmacodynamic components by HPLC method, the pyrogen test of rats was carried out to detect the body temperature of the fever model for 10 h. The low and medium high Dose group, positive group and model group were compared, while the same type of disease commonly used drugs Shuanghuanglian oral solution for synchronous control. Results: Compared with the model group, the difference between the blank group and the model group was statistically significant (P <0.01), the difference was statistically significant (P <0.05), the low, middle and high efficacy The body temperature of rats in group 2 was lower than body temperature of model group during 2 to 6 hours of heating and had obvious antipyretic effect. Conclusion: The pharmacological components (baicalin, chlorogenic acid, xyloside and vitexin) of ruthenium could act as antipyretic components of