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目的:观察米非司酮配伍注射用水湿化米索前列醇阴道置药终止早孕的效果。方法:将符合标准的200例早孕妇女随机分为观察组和对照组各100例,2组均给予米非司酮口服,25 mg/次,2次/日,首剂倍量,至第3日清晨,观察组1小时后给予注射用水湿化米索前列醇400μg阴道放置,对照组予米索前列醇600μg口服。结果:观察组与对照组完全流产率分别为97%和88%;孕囊排出时间分别为(3.21±1.05)h和(4.91±1.43)h;胃肠道反应发生率分别为19.0%和82.0%,两组上述指标比较差异均有统计学意义(P<0.05)。结论:米非司酮150mg配伍注射用水湿化米索前列醇400?g阴道置药是终止早孕的一种有效方法。
OBJECTIVE: To observe the efficacy of mifepristone in combination with water for wet vaginal misoprostol injection to terminate early pregnancy. Methods: A total of 200 pregnant women who met the standard were randomly divided into observation group and control group with 100 cases in each group. Both groups were given mifepristone orally, 25 mg / time, twice daily, the first dose, to the third Day early morning, the observation group was given 1 hour after injection of water humidified misoprostol 400μg vaginal placed in the control group to misoprostol 600μg orally. Results: The complete abortion rates in the observation group and the control group were 97% and 88% respectively; the gestational sac discharge time was (3.21 ± 1.05) h and (4.91 ± 1.43) h respectively; the incidences of gastrointestinal reactions were 19.0% and 82.0% %, There was significant difference between the above two indexes (P <0.05). Conclusion: The combination of mifepristone 150mg and water for injection of 400g misoprostol for vaginal delivery is an effective way to terminate early pregnancy.