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目的研究黄芩苷磷脂复合物在大鼠胃、肠的吸收动力学特征。方法采用大鼠在体胃、肠吸收模型,以高效液相色谱法测定,比较黄芩苷、黄芩苷磷脂复合物以及黄芩苷和卵磷脂的物理混合物胃及全肠段吸收代谢特性;黄芩苷磷脂复合物分肠段吸收代谢特性。结果黄芩苷、黄芩苷磷脂复合物以及黄芩苷和卵磷脂的物理混合物在胃的每小时吸收百分率差异不大。黄芩苷磷脂复合物在小肠全肠段的吸收程度明显优于黄芩苷以及黄芩苷和卵磷脂的物理混合物,其累积吸收量为(2 940.87±1.45)μg,黄芩苷和卵磷脂的物理混合物为(1 373.23±3.21)μg,而黄芩苷最低为(992.66±3.65)μg;黄芩苷磷脂复合物在全肠段有广泛的吸收窗,十二指肠最优,十二指肠、空肠、回肠及结肠的吸收百分率为51.81%、32.29%、29.56%、11.80%。结论当黄芩苷制备成磷脂复合物后,可促进黄芩苷在大鼠胃肠道的吸收。
Objective To study the absorption kinetics of baicalin phospholipid complex in the stomach and intestine of rats. Methods Rat stomach and intestine absorption model were determined by high performance liquid chromatography (HPLC). The absorption and metabolism characteristics of baicalin, baicalin phospholipid complex and the mixture of baicalin and lecithin in the stomach and the whole bowel were compared. Baicalin phospholipid Complex intestinal segment absorption and metabolism characteristics. Results Baicalin, baicalin phospholipid complexes and baicalin and lecithin physical mixture in the stomach per hour absorption percentage difference is not significant. Baicalin phospholipid complex absorption in the intestine of the intestine was significantly better than baicalin and baicalin and lecithin physical mixture, the cumulative absorption was (2 940.87 ± 1.45) μg, baicalin and lecithin physical mixture of (1 373.23 ± 3.21) μg, while the lowest concentration of baicalin was (992.66 ± 3.65) μg. The baicalin phospholipid complex had a wide range of absorption window in the entire bowel segment, duodenum best, duodenum, jejunum, ileum And the percentage of colon absorption was 51.81%, 32.29%, 29.56%, 11.80%. Conclusion When baicalin is prepared into phospholipid complex, it can promote the absorption of baicalin in the gastrointestinal tract of rats.