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目的：为进一步探讨中医药防治儿童哮喘复发及其作用机理。方法：采用扶正固本、活血通络法研制了健肺丸，观察儿童哮喘５６例，并与酮替芬治疗的３０例作对照。结果：总有效率观察组（９１．１％）优于对照组（６０．０％，Ｐ＜０．０１）；血清ＩｇＡ、ＩｇＧ、Ｅ花环的含量用药后明显提高，且优于对照组（Ｐ＜０．０１）；同时肺阻抗血流图之波幅、右心肌指数明显增高（Ｐ＜０．０１），而肺动脉压及肺外周阻力则明显下降（Ｐ＜０．０１）。结论：本品可能通过增强患儿机体免疫功能，改善肺微循环障碍，以控制气道慢性炎症和降低气道高反应性，达到防治本病复发的目的。
Objective: To further explore the prevention and treatment of traditional Chinese medicine asthma relapse and its mechanism of action. Methods: We used Jianzheng Guben and Huoxuetongluo method to develop Jianfei Pill, and observed 56 cases of asthma in children and compared with 30 cases treated with ketotifen. Results: The total effective rate in observation group (91.1%) was superior to that in control group (60.0%, P <0.01). The contents of serum IgA, IgG and E rosette were significantly increased after treatment, (P <0.01). At the same time, the amplitude of pulmonary impedance blood flow diagram and right heart index increased significantly (P <0.01), while pulmonary artery pressure and peripheral lung resistance decreased significantly (P <0.01). Conclusion: This product may improve the immune function in children with improved microcirculation of the lungs in order to control airway chronic inflammation and reduce airway hyperresponsiveness, to prevent the recurrence of the disease.