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目的 观察小剂量抗精神病药舒必利治疗胃十二指肠溃疡的疗效。方法 将 1 0 0例十二指肠溃疡患者随机分成治疗组和对照组。治疗组使用舒必利 0 .1 g、bid服 8周 ,雷尼替丁0 .1 5g、bid服 8周 ,硫糖铝 0 .5g、Tid服 8周 ,阿莫西林 0 .5g、Tid服 2周 ;对照组除不用舒必利外 ,其它所用药物及剂量、服法同治疗组。结果 治疗组治愈率 ( 66% )明显高于对照组 ( 4 6% ) ;起效时间 ( 5.31± 2 .1 7天 )短于对照组 ( 7.56± 2 .7天 ) ;对缓解嗳气、上腹部压痛、OB转阴和解除焦虑、抑郁症状方面优于对照组。结论 舒必利对焦虑、抑郁情绪的康复和促进溃疡的愈合均有良效。
Objective To observe the curative effect of small dose antipsychotic sulpiride on gastroduodenal ulcer. Methods One hundred and ten patients with duodenal ulcer were randomly divided into treatment group and control group. The treatment group used sulpiride 0.1 g, bid for 8 weeks, ranitidine 0.1 5 g, bid for 8 weeks, sucralfate 0.5 g, Tid for 8 weeks, amoxicillin 0 5 g, Tid serving 2 Weeks; except for the control group, sulpiride, other drugs and doses used, the same method with the treatment group. Results The cure rate (66%) in the treatment group was significantly higher than that in the control group (46%). The onset time (5.31 ± 2.17 days) was shorter than that in the control group (7.56 ± 2.7 days) Abdominal tenderness, OB negative and relieve anxiety, depression symptoms better than the control group. Conclusion Sulpiride has good effects on the recovery of anxiety and depression and the healing of ulcer.