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许多细胞因子都具有心血管活性,对心血管系统的功能调节具有重要影响。白细胞介素-8(interleukin-8,IL-8)是单核巨噬细胞合成和释放的,中性粒细胞活化因子。最近发现它亦产生于血管内皮细胞,内皮细胞产生的IL-8具有白细胞粘附抑制因子(LAI)样活性,在炎症反应中限制白细胞在血管壁的粘附而调节白细胞与内皮细胞的相互作用。IL-8不仅
Many cytokines have cardiovascular activity and have a major impact on the functional regulation of the cardiovascular system. Interleukin-8 (IL-8) is a monocyte-macrophage synthesis and release of neutrophil activation factor. It has recently been found that it is also produced by vascular endothelial cells and that endothelial cells produce IL-8 with leukocyte adhesion inhibitor (LAI) -like activity that limits leukocyte adhesion to the vascular wall and regulates the interaction of leukocytes with endothelial cells in the inflammatory response . IL-8 not only