格雷沙星（grepafloxacin，OPC－17116）系日本大制药公司开发的新喹诺酮类合成抗菌剂。结构特点是在喹啉骨架的5位上引入甲基，1位上有环丙基，6位上有氟及7位上有3-甲基哌嗪基。本品对包括肺炎链球菌的革兰氏阳性菌显示出强抗菌力。在革兰氏阴性菌中，对除变形杆菌外的肠内细 Grepafloxacin (OPC-17116) is a new quinolone antibacterial agent developed by Japan’s major pharmaceutical companies. Structural features are the introduction of the methyl group in the 5 position of the quinoline skeleton, cyclopropyl at the 1 position, fluorine at the 6 position and 3-methylpiperazinyl at the 7 position. This product shows strong antimicrobial activity against Gram-positive bacteria including Streptococcus pneumoniae. In Gram-negative bacteria, except for Proteus outside the intestinal fine