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目的 了解系统性红斑狼疮（ＳＬＥ）患者伴发甲状腺功能异常的发生情况。方法 回顾性分析了８４９例有完整病历记录的ＳＬＥ患者资料，记录甲状腺功能异常的发生及临床表现。从中随机抽取 ５０例无甲状腺疾病的ＳＬＥ患者作为对照组，分析其临床表现及实验室指标，并与甲状腺功能异常组比较。结果 ２１例（２．５％）ＳＬＥ患者伴发甲状腺功能异常。其中甲减９例，甲亢５例，桥本氏甲状腺炎２例，亚急性甲状腺炎１例，单纯甲状腺肿２例，甲状腺功能正常病态综合征２例。２１例中１０例行甲状腺抗体检查，８例阳性。结论ＳＬＥ伴发甲状腺疾病并不少见，应予以重视。
Objective To understand the occurrence of thyroid dysfunction in patients with systemic lupus erythematosus (SLE). Methods The data of 849 SLE patients with complete medical record were retrospectively analyzed. The occurrence and clinical manifestations of thyroid dysfunction were recorded. Fifty patients with SLE without thyroid disease were randomly selected as the control group, and their clinical manifestations and laboratory parameters were analyzed, and compared with thyroid dysfunction group. Results 21 cases (2.5%) SLE patients with thyroid dysfunction. Of which 9 cases of hypothyroidism, hyperthyroidism in 5 cases, Hashimoto’s thyroiditis in 2 cases, 1 case of subacute thyroiditis, simple goiter in 2 cases, 2 cases of thyroid dysfunction syndrome. Twenty-one of 21 patients underwent thyroid antibody examination, and 8 were positive. Conclusion SLE with thyroid disease is not uncommon and should be taken seriously.