本实验选用大承气汤、承气合剂及单味大黄对临床腹腔感染患者体内分离出的致病大肠杆菌行体外DNA合成抑制试验.结果表明,随着寒下药物浓度增高,大肠杆菌DNA合成是下降趋势,其抑制 E.coli DNA合成程度几与庆大霉素相同,表明寒下药物抑菌机制是通过抑制细菌的DNA合成,从而抑制致病菌的增殖生长. In this experiment, Dachengqi Decoction, Chengqi Mixture, and single-flavored rhubarb were used to perform in vitro DNA synthesis inhibition assays on pathogenic Escherichia coli isolated from patients with clinical abdominal infections. The results showed that E. coli DNA synthesis was increased with increasing drug concentration in the cold. It is a downward trend, and the degree of inhibition of E.coli DNA synthesis is the same as that of gentamicin, indicating that the antibacterial mechanism of cold drugs is to inhibit bacterial DNA synthesis and inhibit the proliferation of pathogenic bacteria.