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近年来发现阿司匹林类可抑制体内干扰素的形成,使机体抗病毒能力下降,易诱发瑞氏综合征,危害严重.现报道2例并分析如下.例1,患者,女,11岁,于1997年4月8日感冒后眼复方阿司匹林0.84tid×3天.感冒症状好转后突然体温再度升高达40.1℃,头痛重.喷射性呕吐十余次,躁动不安,定向力丧失.颈抵抗感,双克氏征右巴氏征均阳性.脑脊液压力3.5kPa,蛋白士,细胞数108个/mm~3,糖氯化物均正常.血WBC3.7×10~9/L,脑电地型图中度异常,广泛慢波.肝功GPT180u/L.疑阿司匹林致瑞氏综合征.停用阿司匹林,给降颅压,干扰素200万单位impd,降温对症治疗3天后恢复正常.例2,患者,男,8岁,患水痘3天,体温38～39℃.眼复方阿司匹林0.42g×3.5天后体温正常.
In recent years, aspirin was found to inhibit the formation of interferon in vivo, so that the ability of the body to reduce antiviral activity, easy to induce Reye’s syndrome, endangering serious.It is reported in 2 cases and analyzed as follows.Example 1, patients, female, 11 years old, in 1997 April 8, the year after the cold compound aspirin 0.84tid × 3 days .After the symptoms of cold improved suddenly body temperature increased again up to 40.1 ℃, headache .Ejection of vomiting more than ten times, restlessness, loss of orientation .Narrow resistance, double Kirschner wire right Pap smear were positive.Circular pressure 3.5kPa, protein disabilities, the number of cells 108 / mm ~ 3, sugar chloride were normal blood WBC3.7 × 10 ~ 9 / L, EEG type map Degree of abnormalities, a wide range of slow wave.GpT180u / L. suspected Aspirin induced Reye’s syndrome. Aspirin withdrawal, to reduce intracranial pressure, interferon 2000000 units impd, cooling symptomatic treatment after 3 days returned to normal .Example 2, patients, Male, 8 years old, suffering from chickenpox 3 days, body temperature 38 ~ 39 ° C. Eye Compound Aspirin 0.42g × 3.5 days after normal body temperature.