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目的 探讨2型糖尿病患者并发血管病变和感染后的体液免疫状态。方法 采用速率散射免疫比浊法及高亲和力的IgG亚类多克隆抗体 ,测定血清免疫球蛋白和补体。结果 血清IgG水平单纯糖尿病组和血管病变组较对照组显著下降 (分别P<0.05和<0.01) ,并以IgG1 下降为主 ;血清IgG、IgA水平感染组比对照组和单纯糖尿病组显著升高 (P<0.05) ,而IgG亚类及IgM水平感染组无显著变化。结论 糖尿病及并发感染、血管病变患者免疫球蛋白水平失衡
Objective To investigate the status of humoral immunity in patients with type 2 diabetes complicated with vascular lesions and infection. Methods Serum immunoglobulin and complement were measured by the rate-scattering immunoturbidimetry and high-affinity IgG subclass polyclonal antibody. Results Serum IgG levels in diabetic group and vascular group were significantly lower than those in control group (P <0.05 and <0.01, respectively), with the decrease of IgG1. Serum IgG and IgA levels were significantly higher in infected group than in control group and simple diabetic group (P <0.05), but there was no significant change in IgG subclass and IgM infection group. Conclusion The imbalance of immunoglobulin in patients with diabetes mellitus and complicated infection and vascular diseases