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新的氟喹诺酮(Fluoroquinolones)类药物对引起胰腺感染的多种革蓝氏阳性和阴性致病菌有很好的抗菌活力。本研究者在了解丙氟哌酸(Ciprofloxacin)和氟嗪酸(Ofloxacin)在人体胰液中的渗透性和评价其对胰腺感染的可能治疗作用。受试者为7名已行胰腺移植的胰岛素依赖型糖尿病患者,平均年龄37岁,平均病程26年。其中5例因患末期糖尿病肾病,同时行肾脏和胰腺移植。另2例有中度肾功能损害,单行胰腺移植。移植后5～17天中分别给与患者一次口服丙氟哌酸(500mg)或氟嗪酸(400mg),于服药前及服药后0.5、1、1.5、2、3、4、6、8、12和24小时分别采血及收集胰液。血和胰液丙氟哌酸和氟嗪酸浓度通
New Fluoroquinolones have good antibacterial activity against a wide range of Gram-positive and -negative pathogens causing pancreatic infections. The researchers studied the permeability of Ciprofloxacin and Ofloxacin in human pancreatic fluids and evaluated their possible therapeutic effects on pancreatic infections. The subjects were 7 insulin-dependent diabetic patients who had undergone pancreatic transplantation, with a mean age of 37 years and an average duration of 26 years. Five of them suffered from end stage diabetic nephropathy, and had both kidney and pancreas transplantation. The other two cases had moderate renal dysfunction, single pancreas transplantation. 5 to 17 days after transplantation were given to patients with oral administration of propoxyphene acid (500mg) or ofloxacin (400mg), before taking and after taking 0.5,1,1.5,2,3,4,6,8, 12 and 24 hours were collected blood and pancreatic juice. Blood and pancreatic propanoprofen and flunarizine concentration through