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目的:通过分析1例先天性恒牙缺失15颗伴乳牙列患者的临床特点,并结合文献来探讨该病的发生机制。方法:对我院确诊的1例先天性恒牙缺失15颗伴乳牙列患者的临床资料进行分析及文献复习。结果:该患者自幼身体健康,无传染病史和内分泌病史,无创伤及严重感染史,主要临床表现为多数恒牙的缺失,牙列稀疏,过大牙、过小牙及乳牙列同时并存。结论:先天性多颗牙缺失者,并非一定是外胚叶发育不全综合征的表现,非综合征性多颗牙先天缺失也有发生,过大牙过小牙或为牙先天缺失的一种特殊表现,发病机制可能与遗传因子的突变有关。
OBJECTIVE: To investigate the clinical features of one patient with congenital permanent dentin loss in 15 patients with deciduous teeth and to explore the mechanism of the disease by combining the literature. Methods: The clinical data of 1 congenital deciduous permanent dentition with deciduous teeth diagnosed in our hospital were analyzed and reviewed. Results: The patient’s health, non-infectious history and endocrine history, non-invasive and serious infection history, the main clinical manifestations of the majority of permanent tooth loss, dentition sparse, too large teeth, small teeth and deciduous dentition co-exist. Conclusions: Congenital multiple tooth loss is not necessarily the manifestation of ectodermal hypoplasia syndrome, non-syndromic multiple tooth birth defects also occur, too large teeth or small teeth is a special manifestation of tooth congenital absence The pathogenesis may be related to the mutation of genetic factors.