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目的研究EphA4在胃癌胃镜标本和术后标本中的表达,分析其与胃癌生物学行为的关系,探讨其临床价值。方法应用免疫组织化学方法对50例胃癌患者的胃镜标本、术后标本和癌旁组织及淋巴结,正常胃粘膜20例,胃良性病变18例,进行EphA4的检测。结果胃癌组织中EphA4表达水平明显高于癌旁和正常胃组织。EphA4表达与胃癌临床分期、浸润深度和淋巴结转移密切相关(P<0.05)。结论 EphA4在胃癌组织中的表达状态与胃癌的浸润深度和转移关系密切,为胃癌的临床诊断提供了有效的参考。
Objective To investigate the expression of EphA4 in gastroscope specimens and postoperative specimens of gastric cancer and analyze the relationship between the expression of EphA4 and the biological behavior of gastric cancer and its clinical value. Methods Immunohistochemistry was used to detect the expression of EphA4 in 50 cases of gastric cancer by gastroscopy, postoperative specimens and adjacent tissues and lymph nodes, 20 cases of normal gastric mucosa and 18 cases of benign gastric lesions. Results The expression of EphA4 in gastric cancer tissues was significantly higher than that in adjacent normal tissues and normal gastric tissues. EphA4 expression was closely related to clinical stage, depth of invasion and lymph node metastasis (P <0.05). Conclusion The expression of EphA4 in gastric cancer is closely related to the depth of invasion and metastasis of gastric cancer, which provides an effective reference for the clinical diagnosis of gastric cancer.