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基于慢性肾功能不全患者机体状况及自身防卫能力差,同时合并有心、肝、脑等重要器官功能改变、抗生素选择困难等原因,感染是慢性肾功能不全临床处理中最为棘手的问题之一。目前对慢性肾功能不全并感染的处理原则是改善病人一般情况,提高自身防卫能力,注重感染的预防。因而了解尿毒症患者的免疫状态及其受损机理极为重要。其免疫受损机理大致有如下诸方面。
Chronic renal insufficiency is one of the most difficult problems in the clinical treatment of chronic renal insufficiency due to the poor condition of patients with chronic renal insufficiency and their poor self-defense capabilities. In addition, complicated heart, liver, brain and other important organ functions are changed, and antibiotic selection is difficult. The current treatment of chronic renal insufficiency and infection principle is to improve the general condition of patients and improve their defense capabilities, pay attention to the prevention of infection. Therefore, it is very important to understand the immune status of uremic patients and the mechanism of their damage. The mechanism of immune damage generally has the following aspects.