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目的制定苍耳子滴鼻剂的质量标准。方法采用薄层色谱法(TLC)鉴别辛夷、白芷,采用高效液相色谱法(HPLC)测定肉桂酸含量。结果薄层色谱可检出辛夷、白芷,特征斑点圆整清晰,辛夷、白芷阴性对照无干扰;含量测定结果显示,肉桂酸在0.010 02~0.501 0μg范围内线性关系良好,平均加样回收率为102.71%,RSD为1.79%。结论建立的定性定量方法简便,结果准确可靠,专属性强,可有效控制苍耳子滴鼻剂质量。
Objective To establish the quality standard of Xanthium nasal drops. Methods TLC and HPLC were used to determine the contents of cinnamic acid and Angelica dahurica. Results The TLC and HPLC showed that the extract of Magnolia biondii and Angelica dahurica had a clear and complete characteristic spot without interference with the negative control of Magnolia biondii and Angelica dahurica. The determination of content showed good linearity in the range of 0.010 02 ~ 0.501 0 μg with the average recovery of 102.71%, RSD 1.79%. Conclusion The established qualitative and quantitative method is simple, the results are accurate and reliable, the specificity is strong, which can effectively control the Xanthium nasal drops quality.