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目的:探讨诺维本联合顺铂(NP)及紫杉醇联合顺铂(TP)化疗方案辅助治疗老年ⅢA期非小细胞肺癌(NSCLC)的疗效及不良反应。方法:对2009年1月至2012年10月于我院肿瘤科住院治疗的43例老年(≥65岁)ⅢA期NSCLC患者进行化疗,分别使用诺维本联合顺铂(NP组,n=23)和紫杉醇联合顺铂(TP组,n=20)治疗,比较两组的疗效及不良反应。结果:NP组6例完全缓解,9例部分缓解,总有效率65.2%,疾病控制率82.6%;TP组6例完全缓解,7例部分缓解,总有效率65.0%,疾病控制率80.0%,两组疗效无显著差异;TP组死亡2例显著高于NP组死亡1例,(P<0.05);NP组肝功能损害Ⅰ度+Ⅱ度12例,Ⅲ度+Ⅳ度1例,TP组肝功能损害Ⅰ度+Ⅱ度11例,Ⅲ度+Ⅳ度6例,差异明显(P=0.03),其余不良反应,如白细胞减少、血小板减少、贫血、恶心呕吐、肾功能损害及脱发等均无明显差异(P>0.05)。结论:NP化疗方案辅助治疗老年ⅢA期NSCLC疗效好,不良反应少,值得推广。
Objective: To investigate the efficacy and adverse reactions of Novolin combined with cisplatin (NP) and paclitaxel combined with cisplatin (TP) chemotherapy in the treatment of elderly patients with stage Ⅲ A non-small cell lung cancer (NSCLC). Methods: Forty-three elderly patients (≥65 years old) with stage Ⅲ A NSCLC who underwent in-hospital inpatient oncology in our hospital from January 2009 to October 2012 were enrolled in this study. The patients were treated with nocitin and cisplatin (n = 23 ) And paclitaxel combined with cisplatin (TP group, n = 20). The curative effect and adverse reactions of the two groups were compared. Results: In NP group, 6 cases were completely relieved, 9 cases partially relieved, the total effective rate was 65.2% and disease control rate was 82.6%. Six cases in TP group were completely relieved and 7 cases partially relieved. The total effective rate was 65.0% and disease control rate was 80.0% There was no significant difference between the two groups. Two cases died in TP group and one case died in NP group (P <0.05). In NP group, 12 cases were grade Ⅰ + Ⅱ degree and 1 case was grade Ⅲ + Ⅳ in TP group There were 11 cases with grade Ⅰ + Ⅱ degree and 6 cases with Ⅲ degree + Ⅳ degree of liver damage (P = 0.03). Other adverse reactions such as leukopenia, thrombocytopenia, anemia, nausea and vomiting, renal dysfunction and alopecia No significant difference (P> 0.05). Conclusion: NP chemotherapy adjuvant treatment of elderly patients with stage Ⅲ A NSCLC good efficacy, fewer adverse reactions, it is worth promoting.