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目的通过分析血清肌酸激酶(CK)及其同工酶(CK-MB)与窒息新生儿及并发缺氧缺血性脑病(HIE)患儿之间的关系,探讨血清肌酸激酶(CK)及其同工酶(CK-MB)对窒息新生儿诊断的临床意义。方法分别应用全自动血生化分析仪测定62例窒息新生儿和20例正常新生儿血清CK、CK-MB水平,统计学分析各指标的差异。结果窒息组血清CK、CK-MB水平显著高于对照组(P<0.01);重度窒息组水平显著高于轻度窒息组(P<0.01);26例窒息儿合并新生儿缺氧缺血性脑病(HIE),其血清CK、CK-MB水平明显高于未合并HIE的新生儿(P<0.01)。结论血清CK、CK-MB水平测定可用于新生儿窒息的诊断,并有助于判断新生儿窒息预后。
Objective To investigate the relationship between serum creatine kinase (CK) and its isoenzyme (CK-MB), asphyxia neonates and children with hypoxic-ischemic encephalopathy (HIE) And its isoenzyme (CK-MB) in the diagnosis of neonatal asphyxia. Methods The levels of serum CK and CK-MB in 62 neonates with asphyxia and 20 normal neonates were detected by automatic blood biochemical analyzer respectively. The differences of each index were statistically analyzed. Results Serum levels of CK and CK-MB in asphyxia group were significantly higher than those in control group (P <0.01), severe asphyxia group was significantly higher than that in mild asphyxia group (P <0.01), 26 asphyxia children with hypoxic-ischemic Encephalopathy (HIE), serum CK, CK-MB levels were significantly higher than those without HIE neonates (P <0.01). Conclusion Serum levels of CK and CK-MB can be used in the diagnosis of neonatal asphyxia and help to determine the prognosis of neonatal asphyxia.