羟基蛋氨酸钙是复方α-酮酸片中一个重要成分,可防止氨基酸缺乏和改善代谢紊乱,对肾功能衰竭具有一定的疗效,并对钙代谢和继发性甲状旁腺功能亢进都具有益作用,同时也是重要的有机合成、药物合成及生物合成中间体。本文对近年来羟基蛋氨酸及其钙盐的合成方法进行了综述。重点介绍了氰醇水解法、蛋氨酸转化法、酮酸转化法、酮醇氧化法、氰代磷酸二乙酯法和α-羟基-γ-丁内酯法等在羟基蛋氨酸及其钙盐合成中的应用。 Calcium hydroxymethionine is an important component of compound alpha-ketoacid tablets, which can prevent the lack of amino acids and improve the metabolic disorder, has a certain effect on renal failure, and has a beneficial effect on calcium metabolism and secondary hyperparathyroidism , But also important organic synthesis, drug synthesis and biosynthesis intermediates. In this paper, hydroxy methionine and its synthesis of calcium salts were reviewed in recent years. In this paper, the synthesis of hydroxymethionine and its calcium salt by cyanohydrin, methionine, ketoacid, ketol oxidation, diethyl cyanophosphate and α-hydroxy-γ-butyrolactone Applications.