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育龄期无排卵是指育龄女性长期无卵子成熟排出的病理状态,是女性不孕症的主要原因之一。育龄期无排卵多伴随着闭经或严重的月经过少。世界卫生组织将无排卵分为WHOⅠ~Ⅲ类。育龄期无排卵主要病因可分为下丘脑功能紊乱、垂体疾病、卵巢功能异常;其他内分泌腺体如甲状腺和肾上腺功能异常亦可能导致无排卵。卵巢功能异常所致的无排卵病因包括:先天性卵巢发育异常、卵巢抵抗综合征(resistant ovarian syndrome,ROS)、卵巢早衰(premature ovarian failure,POF)、多囊卵巢综合征(polycystic ovary syndrome,PCOS)、未破裂卵泡黄素化综合征(luteinized unruptured follicle syndrome,LUFS),最常见者为POF和PCOS。全身性疾病的恶性循环可影响排卵机制。环境中有害物质尤其是环境激素,对人类生殖的不良影响已被确认。育龄期无排卵病因复杂,准确评估和定位病因是有效治疗的关键。
Child-rearing ovulation is the pathological state of fertility-free long-term egg-free mature female infertility is one of the main reasons. Childhood anovulation associated with amenorrhea or severe menorrhagia. WHO will no ovulation into WHO Ⅰ ~ Ⅲ category. The main causes of ovulation at childbearing age can be divided into hypothalamic dysfunction, pituitary disease, ovarian dysfunction; other endocrine glands such as thyroid and adrenal dysfunction may also lead to anovulation. Ovarian dysfunction caused by anovulatory causes include: congenital ovarian dysplasia, ovarian syndrome (resistant ovarian syndrome, resistant ovarian syndrome (resistant ovarian failure, POF, polycystic ovary syndrome (PCOS ), Unruptured luteinized unruptured follicle syndrome (LUFS), the most common being POF and PCOS. The vicious cycle of systemic disease can affect the ovulation mechanism. Environmental harmful substances, especially environmental hormones, adverse effects on human reproduction have been identified. Age-related causes of anovulatory complications, accurate assessment and positioning of the etiology is the key to effective treatment.