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目的 :探讨上颌窦鳞癌组织中 p5 3蛋白表达的诊断意义及其与复发及预后的关系。方法 :采用鼠单克隆抗体 DO- 7,免疫组化法检测 45例上颌窦鳞状细胞癌患者 (T2 N0 M0 )手术切除的癌组织中 p5 3蛋白含量 ,其过量表达提示 p5 3基因突变体存在。结果 :复发组中 88.2 %的癌组织中有 p5 3蛋白表达 ,显著高于对照组(2 8.6 % ) ,其差异有极显著性意义 (P <0 .0 1)。复发组中 6 1%的癌组织有较强的染色强度 ,高于对照组 (38% ) ,但其差异无显著性意义 (P >0 .0 5 )。结论 :p5 3蛋白可作为预测上颌窦鳞癌复发的基因水平的标记物 ,对其复发及预后具有重要意义。
Objective: To investigate the significance of p5 3 protein expression in squamous cell carcinoma of the maxillary sinus and its relationship with recurrence and prognosis. Methods: The protein level of p5 3 in cancerous tissue of 45 patients with maxillary sinus squamous cell carcinoma (T2N0 M0) was detected by using mouse monoclonal antibody DO-7 and immunohistochemistry. The overexpression of p5 3 protein exist. Results: The expression of p5 3 in 88.2% of the cancerous tissues in the recurrent group was significantly higher than that in the control group (22.6%), the difference was significant (P <0.01). The recurrence group 6 1% of the cancer tissue staining intensity, higher than the control group (38%), but the difference was not significant (P> 0.05). Conclusion: p5 3 protein can be used as a marker of gene expression in predicting the recurrence of maxillary sinus squamous cell carcinoma, which is of great significance for its recurrence and prognosis.