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应用抗甲状腺药物治疗Graves病,至今已有四十多年的历史。目前国内外常用的这类药物仍以硫代酰胺类为主,包括丙基硫氧嘧啶、甲基硫氧嘧啶、甲硫咪唑(即他巴唑)和甲亢平。在过去的四十年里,甲状腺疾病的病因和发病机制的研究(尤其是在免疫机制方面)取得了令人注目的进展,人们对抗甲状腺药物的药理作用机制也有了更多的了解。越来越多的研究证实,其活性范围要比最初人们认为的广得多,而且具有不少有重要临床意义的“甲状腺外作用”。本文仅就硫代酰胺类抗甲状腺药物的药理及临床近况作一简单介绍。
Anti-thyroid drug treatment of Graves disease, has been more than 40 years of history. At present, the commonly used drugs at home and abroad are still mainly thioamides, including propylthiouracil, methylthiouracil, methimazole (ie, methimazole) and hyperthyroidism. In the past four decades, there has been notable progress in the study of the etiology and pathogenesis of thyroid diseases, especially in the area of immune mechanisms, and there is a greater understanding of the pharmacological mechanisms of thyroid drugs. More and more studies confirm that the scope of its activity than originally thought to be much broader, and has a lot of important clinical significance of “extra-thyroidal effect.” This article only thioamide antithyroid drugs pharmacology and clinical status make a brief introduction.