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目的:探讨左甲状腺素钠治疗老年甲状腺功能减退综合征的临床疗效以及安全性。方法:选取我院收治的62例老年甲状腺功能减退综合征患者,将患者随机分为对照组和观察组。比较两组患者的临床疗效、治疗前后的甲状腺激素变化差异、不良反应发生率。结果:观察组和对照组的总有效率分别为90.32%、64.52%,观察组显著优于对照组(P<0.05);两组患者的FT4、FT3以及TSH水平与治疗前相比均得到显著改善(P<0.05),两组患者治疗后的FT4、FT3以及TSH水平同期相比(P<0.05);对照组和观察组总的不良反应发生率分别为19.35%、6.45%,对照组显著高于观察组(P<0.05)。结论:左甲状腺素钠治疗老年性甲状腺功能减退综合征疗效切确、安全性高,值得临床推广。
Objective: To investigate the clinical efficacy and safety of levothyroxine in the treatment of senile hypothyroidism syndrome. Methods: 62 elderly patients with hypothyroidism admitted to our hospital were selected and randomly divided into control group and observation group. The clinical efficacy of the two groups were compared, the changes of thyroid hormone before and after treatment, the incidence of adverse reactions. Results: The total effective rates of the observation group and the control group were 90.32% and 64.52%, respectively, and the observation group was significantly better than the control group (P <0.05). The FT4, FT3 and TSH levels in both groups were significantly higher than those before treatment (P <0.05). The FT4, FT3 and TSH levels in the two groups were significantly higher than those in the control group (P <0.05). The incidences of adverse reactions in the control group and the observation group were 19.35% and 6.45% Higher than the observation group (P <0.05). Conclusion: The effect of levothyroxine in the treatment of senile hypothyroidism syndrome is accurate, safe and worthy of clinical promotion.