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谷氨酰胺对快速增殖细胞的代谢来讲是重要的能量来源。肿瘤早期肿瘤细胞主要通过葡萄糖的有氧酵解供能,随着肿瘤增长,为满足肿瘤对能量等物质的需求,肿瘤周围的间质细胞发生自噬,这一过程为肿瘤细胞的代谢提供了谷氨酰胺和其他大分子物质。与正常组织细胞相比,肿瘤细胞似乎更需要和利用谷氨酰胺。
Glutamine is an important source of energy for the metabolism of rapidly proliferating cells. Early tumor cells mainly through the aerobic glycolysis of glucose energy supply, as the tumor growth, in order to meet the tumor’s demand for energy and other substances, interstitial cells around the tumor autophagy, the process for the metabolism of tumor cells provided Glutamine and other macromolecular substances. Tumor cells appear to require and utilize glutamine more than normal tissue cells.