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目的探讨苯磺酸氨氯地平治疗轻、中度原发性高血压的临床疗效。方法选择临床确诊的86例轻、中度原发性高血压患者,随机分为治疗组(氨氯地平组)和对照组(硝苯地平缓释片组),治疗组46例,对照组40例。治疗组使用苯磺酸氨氯地平5~10 mg,1次/d,疗程为8周,对照组使用硝苯地平缓释片10~20 mg,1次/d,疗程为8周。结果治疗组有效率为93%,对照组有效率为70%,其差异有统计学意义(P<0.05)。结论氨氯地平组的总有效率高于硝苯地平组,不良反应也较少,安全性较高,用药方便,价格低廉,尤其适合基层医院推广。
Objective To investigate the clinical efficacy of amlodipine besylate in the treatment of mild to moderate essential hypertension. Methods A total of 86 patients with mild to moderate essential hypertension were selected and randomly divided into treatment group (amlodipine group) and control group (nifedipine sustained-release tablets group), 46 cases in the treatment group and 40 cases in the control group example. The treatment group used amlodipine besylate 5 to 10 mg once daily for 8 weeks. The control group used nifedipine extended release tablets 10 to 20 mg once daily for 8 weeks. Results The effective rate was 93% in the treatment group and 70% in the control group, the difference was statistically significant (P <0.05). Conclusion The total effective rate of amlodipine group is higher than that of nifedipine group, with fewer adverse reactions, higher safety, convenient medication and lower cost, especially suitable for the promotion of primary hospitals.