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安乃近注射液易变色,其颜色在配液过程即已呈现,灭菌后可变浅,短时(至25天)存放中能继续变淡,但长期贮存会重新加深,而贮存期的色泽变化与熔封时填充N_2、Co_2等惰性气体与否无关。由于安乃近分子中含有4-CH_2SO_3Na极性基团,在水溶液中有很强的反应活性,因此,阐明50％安乃近水溶液可否发生水解,水解产物是否为贮存中的变色因素则是非常必要的。在研究安乃近水溶液的水解反应中,发现pH2.0—12.0时有水解产物产生。用薄层层析、液相萃取、红外和核磁共振(ПМР)
Ambroxol injection easily discolored, its color has been presented in the dosing process, after sterilization can be shallow, short (up to 25 days) storage can continue to fade, but long-term storage will deepen, and the storage period Color change and fusing filled N_2, Co_2 and other inert gas has nothing to do. Because of its 4-CH_2SO_3Na polar group in the molecule, it has a strong reactivity in aqueous solution. Therefore, elucidation of whether 50% metamizol could hydrolyze and whether the hydrolyzate is a discoloring factor in storage is very significant necessary. In the study of the hydrolysis reaction of aqueous solution of Arndanone, hydrolyzate was found to occur at pH 2.0-12.0. Thin-layer chromatography, liquid-phase extraction, infrared and nuclear magnetic resonance (ПМР)