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目的调查实践中2型糖尿病患者使用降糖药物与低血糖事件发生的相关性。方法回顾总结兰州大学第二医院VIP糖尿病科2型糖尿病合并药物性低血糖患者的病例资料,对150例研究对象进行分析,收集了性别、年龄、降糖药物使用情况等数据,对收集的相关变量先进行单因素卡方检验,再将上述因素进行多因素Logistic回归分析。结果单因素分析结果显示有差异的变量是单用胰岛素、联合用药种类,多因素Logistic回归分析结果显示不同年龄组2型糖尿病患者低血糖的发生与单用胰岛素及联合用药种类有关系。结论不同年龄组的2型糖尿病患者发生药物性低血糖与单用胰岛素及降糖药物的联合用药种类相关。
Objective To investigate the relationship between hypoglycemic agents and hypoglycaemic events in patients with type 2 diabetes in practice. Methods The data of patients with type 2 diabetes mellitus complicated with drug-induced hypoglycemia in the Department of Diabetes of the Second Hospital of Lanzhou University were retrospectively reviewed. Data of 150 subjects were analyzed, and the data of sex, age and the use of antidiabetic drugs were collected. The variables were first univariate chi-square test, and then the above factors were multivariate Logistic regression analysis. Results The results of univariate analysis showed that there was a difference in the variables of insulin alone, combined medication types, multivariate Logistic regression analysis showed that different age groups with type 2 diabetes hypoglycemia occurred with single insulin and combination of drug types. Conclusions The occurrence of drug-induced hypoglycemia in patients with type 2 diabetes mellitus at different age groups is associated with the combination of insulin and hypoglycemic drugs alone.