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目的:分析讨论TP诱导联合DDP同期放化疗治疗局部晚期食管癌临床疗效。方法:选取2013年1月至12月末我院收治的食管癌患者118例,随机分为两组,A组(58例)行TP诱导,于第30天开始放疗;B组(60例)TP诱导化疗联合DDP同期放疗、化疗。两组TP诱导化疗方案:多西紫衫醇65mg/m2,第30天开始顺铂75mg/m2。3周进行1次,共进行2个周期。结果:A组治疗过程中主要产生血液毒性作用,B组也产生血液毒性,但也伴有口腔黏膜反应。治疗后B组食管病灶缓解率(60.0%)显著高于A组(55.1%),其差异有统计学意义。且B组的不良反应发生率也低于A组。结论:采用TP诱导联合DDP同期放化疗治疗局部晚期食管癌,近期效果较好,毒副反应并未增强,患者可耐受,值得临床推广应用。
Objective: To analyze and discuss the clinical efficacy of TP induction combined with concurrent DDP radiotherapy and chemotherapy for locally advanced esophageal cancer. Methods: 118 patients with esophageal cancer treated in our hospital from January to December 2013 were randomly divided into two groups. Group A (58 cases) underwent TP induction and started radiotherapy on the 30th day. Group B (60 cases) TP Induction chemotherapy combined with DDP radiotherapy and chemotherapy. Two groups of TP induction chemotherapy regimen: docetaxel 65mg / m2, the first 30 days of cisplatin 75mg / m2 once every 3 weeks, a total of 2 cycles. Results: Hematotoxicity mainly occurred in the treatment of group A and hematotoxicity in group B, but also oral mucosal reaction. After treatment, the remission rate of esophageal lesions in group B (60.0%) was significantly higher than that in group A (55.1%), the difference was statistically significant. The incidence of adverse reactions in group B was also lower than that in group A. Conclusion: The combination of TP induction and concurrent radiotherapy and chemotherapy of DDP in the treatment of locally advanced esophageal cancer, the recent effect is better, the side effects did not increase, the patient is tolerable, worthy of clinical application.