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目的 为探讨冠心病有无心绞痛时左心室功能与并发症是否具有缺血预适应的保护作用。方法 连续观察了 14 7例冠心病住院患者左室舒张功能、收缩功能及临床并发症的变化。结果 ① 65例急性心肌梗塞患者中有心绞痛组左室舒张、收缩功能及心律失常、心力衰竭和病死率均比无心绞痛组减少 (P <0 .0 5 ) ;② 82例无急性心肌梗塞患者中左室舒张、收缩功能及临床各种并发症 ,心绞痛组也比无心绞痛组减少 ,但无统计学差异 (P >0 .0 5 )。结论 ①心肌梗塞前发生心绞痛可使缺血心肌产生预适应效应。②慢性持续性非梗塞性的心肌缺血可减弱或阻抑缺血预适应现象的产生。
Objective To investigate whether left ventricular function and complications with ischemic preconditioning protect against coronary heart disease with or without angina pectoris. Methods The changes of left ventricular diastolic function, systolic function and clinical complications in 147 inpatients with coronary heart disease were observed continuously. Results ① In 65 patients with acute myocardial infarction, left ventricular diastolic and systolic function, arrhythmia, heart failure and mortality were decreased in patients with angina pectoris group (P <0.05). ② In 82 patients without acute myocardial infarction Middle-left ventricular diastolic and systolic function and clinical complications, angina group than non-angina group decreased, but no significant difference (P> 0.05). Conclusions Angina pectoris before myocardial infarction can produce preconditioning effect on ischemic myocardium. ② chronic persistent non-infarcted myocardial ischemia can reduce or suppress the occurrence of ischemic preconditioning.