癌基因和抑癌基因存在于所有的细胞中,行使重要的功能。本文综述了近年来的研究进展,特别是新近发现的多肿瘤抑制基因,在75％的各种癌细胞中发生突变,它所编码的蛋白质之—P~(16)是目前为止发现的第一个直接控制细胞增殖周期的固有成份,在癌发生机制方面给我们提供了前所未有的认识。 Oncogenes and tumor suppressor genes are present in all cells and perform important functions. This article reviews the research progress in recent years, especially the recently discovered multi-tumor suppressor gene, which has been mutated in 75% of various cancer cells. The protein encoded by it, P 16 is the first to date The intrinsic components that directly control the cell proliferation cycle have provided us with an unprecedented understanding of the carcinogenesis mechanism.