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目的:研究KiSS-1和MMP-9在鼻咽癌组织中的表达及其与淋巴结转移的关系。方法:应用免疫组化SP法检测23例慢性鼻咽炎、62例鼻咽癌组织(其中38例伴有颈部淋巴结转移)中KiSS-1和MMP-9的表达。结果:62例鼻咽癌组织KiSS-1和MMP-9阳性表达率分别为45.2%和75.8%,23例慢性鼻咽炎两者阳性率分别为95.7%和13.0%,差异均有统计学意义,P<0.05;鼻咽癌转移组和非转移组KiSS-1阳性率分别为26.3%和75.0%,差异有统计学意义,P<0.05;鼻咽癌转移组和非转移组MMP-9阳性率分别为89.4%和54.2%,转移组明显高于非转移组,差异有统计学意义,P<0.05。相关分析显示,KiSS-1和MMP-9表达呈负相关。结论:KiSS-1和MMP-9异常表达与鼻咽癌的转移有关,有助于判断患者的预后。
Objective: To investigate the expression of KiSS-1 and MMP-9 in nasopharyngeal carcinoma and its relationship with lymph node metastasis. Methods: The expressions of KiSS-1 and MMP-9 in 23 cases of chronic nasopharyngitis and 62 cases of nasopharyngeal carcinoma (including 38 cases with cervical lymph node metastasis) were detected by immunohistochemical SP method. Results: The positive rates of KiSS-1 and MMP-9 in 62 cases of nasopharyngeal carcinoma were 45.2% and 75.8% respectively, and the positive rates of 23 cases and 23 cases of chronic nasopharyngitis were 95.7% and 13.0% respectively. The differences were statistically significant, P <0.05; The positive rates of KiSS-1 in nasopharyngeal carcinoma metastasis group and non-metastasis group were 26.3% and 75.0% respectively, the difference was statistically significant, P <0.05; The positive rate of MMP-9 in NPC group and non-metastasis group Respectively, 89.4% and 54.2%, the metastasis group was significantly higher than the non-metastasis group, the difference was statistically significant, P <0.05. Correlation analysis showed that KiSS-1 and MMP-9 expression was negatively correlated. Conclusion: The abnormal expression of KiSS-1 and MMP-9 is related to the metastasis of NPC, which can help to judge the prognosis of patients.