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自1885年Pommer首次将骨质疏松与骨软化区别开以来,钙缺乏在人骨质疏松发病机制中的作用一直存在争论。上世纪30-40年代,Albright的雌激素缺乏理论统治着骨质疏松领域,只承认钙缺乏能导致骨软化;1960年Nordin等的动物实验再次证实饮食缺钙可导致骨质疏松;此后, Matkovic的流行病学研究结果证明了缺钙可导致骨质疏松,使钙对骨质疏松的防治作用得到学术界
Since Pommer first distinguished osteoporosis from osteomalacia in 1885, the role of calcium deficiency in the pathogenesis of human osteoporosis has been debated. In the 1930s and 1940s, Albright’s theory of estrogen deficiency dominated the field of osteoporosis, admitting that calcium deficiency alone can lead to osteomalacia. Animal experiments such as Nordin et al. In 1960 confirmed once again that calcium deficiency in the diet leads to osteoporosis; thereafter, Matkovic Epidemiological studies have shown that calcium deficiency can lead to osteoporosis, calcium prevention and treatment of osteoporosis has been the academic community