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为肾移植术后患者合理应用抗高血压药物提供依据。方法：采用ＦＰＩＡ法测定环孢素全血药物浓度，６例肾移植术后患者在合并应用苯那普利前、合用７ｄ后、停药后第７天，分别测定血清肌酐、尿素氮、环孢素血药浓度、血压。结果：患者合并用苯那普利前、后的血清肌酐、尿素氮、环孢素血药浓度经统计学检验无显著性差异（Ｐ＞０．０５），合并用药后血压较合并用药前有显著下降（收缩压降低Ｐ＜０．０１，舒张压降低Ｐ＜０．０５）。结论：苯那普利与环孢素合并用药时能对抗环孢素相关性高血压，但对患者的肾功能无不良影响，且基本不改变环孢素的血药浓度。
Provide basis for rational use of antihypertensive drugs in patients after renal transplantation. Methods: The concentration of cyclosporine whole blood was determined by FPIA method. Six patients after renal transplantation were treated with benazepril, 7 days after treatment and 7 days after treatment. Serum creatinine, urea nitrogen, Sporin blood concentration, blood pressure. Results: Serum creatinine, urea nitrogen and cyclosporine blood concentration in patients before and after combination of benazepril had no significant difference (P> 0.05). The blood pressure after combination therapy was significantly higher than that before combination therapy (P <0.01 for systolic pressure and P <0.05 for diastolic pressure). CONCLUSION: Benazepril combined with cyclosporine can antagonize cyclosporine-related hypertension, but has no adverse effect on renal function of patients and basically does not change the plasma concentration of cyclosporine.