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目的 研究脑卒中急性期患者血清Leptin(瘦素)水平及与血压、血清胰岛素、血糖、血脂的关系。方法用放射免疫分析法测定183例急性脑血管病患者血清Leptin水平,其中脑梗死119例(男65例,女54例),脑出血64例(男41例,女23例),并同时测定空腹血糖、血清胰岛素、血脂,且与137例健康体检者进行对照。结果 男性脑梗死及脑出血患者的Leptin水平高于男性对照组(P<0.01),且以男性脑出血患者增高更明显。女性脑出血组的Leptin水平高于女性对照组(P<0.01)。脑出血急性期患者血清Leptin水平与血糖呈正相关(r=0.48,P<0.01),与血清胰岛素呈正相关(r=0.58,P<0.01),与血压呈正相关(r=0.37,P<0.05),与高密度脂蛋白呈负相关(r=-0.38,P<0.01)。急性脑梗死患者血清Leptin水平与血清胰岛素呈正相关(r=0.47,P<0.01),与高密度脂蛋白呈负相关(r=-0.30,P<0.05。结论 急性脑血管病患者血清Leptin水平升高,是神经内分泌功能紊乱的表现,是脑出血急性期患者的危险因素之一。
Objective To study the relationship between leptin level and blood pressure, serum insulin, blood glucose and blood lipid in patients with acute stroke. Methods Serum Leptin levels were measured by radioimmunoassay in 183 patients with acute cerebrovascular disease, including 119 cerebral infarction (65 males and 54 females) and 64 cerebral hemorrhage (41 males and 23 females) Fasting blood glucose, serum insulin, lipids, and with 137 healthy subjects were compared. Results The level of Leptin in male patients with cerebral infarction and cerebral hemorrhage was higher than that in male controls (P <0.01), and the increase was more obvious in male patients with cerebral hemorrhage. Leptin levels in female ICH group were higher than those in female control group (P <0.01). The level of Leptin in patients with acute cerebral hemorrhage was positively correlated with blood glucose (r = 0.48, P <0.01) and positively correlated with serum insulin (r = 0.58, P <0.01) , But negatively correlated with high density lipoprotein (r = -0.38, P <0.01). The level of Leptin in patients with acute cerebral infarction was positively correlated with serum insulin (r = 0.47, P <0.01), and negatively correlated with high density lipoprotein (r = -0.30, P <0.05) .Conclusion Serum Leptin level in patients with acute cerebrovascular disease High, is a manifestation of neuroendocrine disorders, is one of the risk factors for patients with acute cerebral hemorrhage.