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1.短期大剂量DNP皮下注射12次经45天后12只大鼠全部出现鼻腔癌前期病变,动物延至160天全部出现癌,作者认为可用作鼻腔、鼻咽癌前期的动物实验模型;2.维甲酰胺对癌的发生有抑制作用,其机制可能是抑制或逆转癌变过程中的鳞化过程。维甲酰胺还表现出对急、慢性炎症反应有抑制作用;3.DNP诱发的鼻腔上皮病变中出现的急、慢性炎症可能是上皮病变的伴发反应和机体免疫状态的反映。
1. Short-term high-dose DNP subcutaneous injection 12 times after the first 45 days after the emergence of all the 12 rats precancerous lesions of the nasal cavity, the animal was delayed until 160 days of all cancers, the author believes that can be used as an animal model of nasal cavity, nasopharyngeal precancerous animal model; Retinamide has an inhibitory effect on the occurrence of cancer, and its mechanism may be to inhibit or reverse the scale process in the process of carcinogenesis. Retinamide also exhibits an inhibitory effect on acute and chronic inflammatory reactions. 3. Acute and chronic inflammation in DNP-induced epithelial lesions of the nasal cavity may be a reflection of the associated reactions of epithelial lesions and the immune status of the body.