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目的:观察罗格列酮对高胆固醇饮食兔血脂和组织总抗氧化能力的影响,探讨罗格列酮对动脉粥样硬化斑块消退的机制。方法:雄性新西兰大白兔24只随机等分为3组:对照组、胆固醇组、罗格列酮组。罗格列酮从第10周开始干预,16周后,测定血脂、血糖水平,主动脉行病理形态学及颈动脉组织总抗氧化能力的检测。结果:与对照组和胆固醇组相比,16周末时罗格列酮组血清总胆固醇、低密度脂蛋白胆固醇均明显降低;主动脉壁斑块数量和斑块面积显著减少;颈动脉组织总抗氧化能力明显增强。结论:罗格列酮对动脉粥样硬化斑块消退作用的其机制之一可能与降低血清总胆固醇、低密度脂蛋白胆固醇水平及增强组织总抗氧化能力有关。
OBJECTIVE: To observe the effect of rosiglitazone on the total cholesterol and lipid peroxidation in hypercholesterolemic rabbits and to explore the mechanism of rosiglitazone on the regression of atherosclerotic plaques. Methods: Twenty-four New Zealand white rabbits were randomly divided into three groups: control group, cholesterol group and rosiglitazone group. Rosiglitazone intervention began from the 10th week. After 16 weeks, the levels of blood lipids, blood glucose, aortic pathomorphology and carotid artery total antioxidant capacity were measured. Results: Serum total cholesterol (LDL) and low density lipoprotein cholesterol (LDL-C) were lower in rosiglitazone group than those in control group and cholesterol group at the end of 16th week. The number of plaque and plaque area in aorta wall were significantly decreased. Oxidation capacity was significantly enhanced. Conclusion: One of the mechanisms of rosiglitazone on the regression of atherosclerotic plaques may be related to the reduction of serum total cholesterol, low density lipoprotein cholesterol and enhancement of total anti-oxidative capacity.