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[摘要] 目的 研究重组人干扰素α-1b联合细菌溶解产物在治疗反复呼吸道感染患儿免疫功能的疗效评价。 方法 选取我院从2013年6月～2014年6月入院治疗的151例反复呼吸道感染患儿做为研究对象，另选取正常儿童20例做为正常对照组。所有患儿均在常规治疗方法的基础上应用重组人工干扰素α-1b联合细菌溶解产物治疗。利用流式细胞术、电化学发光法，在其患病时、呼吸道症状消失后4周，及健康患儿，分别检测其血清中T细胞水平、血清皮质（COR）的含量变化，比较三者之间细胞免疫状态的差异与血清皮质醇的含量变化。 结果 恢复组患儿体内血清T淋巴细胞CD3 、CD4 及血清COR水平显著高于发病组，而T淋巴细胞CD8 水平显著低于发病组，差异具有统计学意义（P<0.05）。发病组患儿体内血清T淋巴细胞CD3 、CD4 及血清COR水平显著低于正常对照组，而T淋巴细胞CD8 水平显著高于正常对照组，差异具有统计学意义（P<0.05）。 结论 反复呼吸道感染患儿体内免疫功能出现紊乱，重组人干扰素α-1b联合细菌溶解产物具调节患儿免疫系统的作用，提高免疫力，临床效果显著，值得广泛推广应用。
[关键词] 重组人干扰素α-1b；细菌溶解产物；反复呼吸道感染；免疫功能
[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701（2015）01-0043-03
Influence of recombinant human interferon α-1b combined with bacterial lysates on immune function of children with recurrent respiratory tract infection
ZHU Chaohai ZHANG Yi XIE Hairui LAI Zhiguang
The Emergency Department， Guangzhou Yuexiu District Children’s Hospital， Guangzhou 510115， China
[Abstract] Objective To evaluate the efficacy of recombinant human interferon α-1b combined with bacterial lysates for the immune function of children with recurrent respiratory tract infection. Methods All 151 children with recurrent respiratory tract infection hospitalized and treated in our hospital from June 2013 to June 2014 were selected as the study subjects and 20 normal children were selected as the normal control group. All the children received recombinant human interferon α-1b combined with bacterial lysates treatment on the basis of conventional treatment. The flow cytometry and electrochemiluminescence were used to detect the changes in serum T cell levels and serum corticosterone （COR） contents of the sick children during illness and 4 weeks after respiratory symptom disappearance and of the healthy children. The differences in cell immune state and the changes of serum cortisol contents between the three types were compared. Results The serum T lymphocytes CD3 and CD4 and serum COR levels of the recovery group were significantly higher than those of the attack group， but the T lymphocyte CD8 level was significantly lower than that of the attack group， with statistically significant differences （P<0.05）. The T lymphocytes CD3 and CD4 and serum COR levels of the attack group were significantly lower than those of the normal control group， but the T lymphocyte CD8 level was significantly higher than that of the normal control group， with statistically significant difference （P<0.05）. Conclusion The immune function of children with recurrent respiratory tract infection is disorganized. Recombinant human interferon α-1b combined with bacterial lysates can regulate immune system， improve immune function and exert significant clinical effects， thereby worthy of wide promotion and application.
[关键词] 重组人干扰素α-1b；细菌溶解产物；反复呼吸道感染；免疫功能
[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701（2015）01-0043-03
Influence of recombinant human interferon α-1b combined with bacterial lysates on immune function of children with recurrent respiratory tract infection
ZHU Chaohai ZHANG Yi XIE Hairui LAI Zhiguang
The Emergency Department， Guangzhou Yuexiu District Children’s Hospital， Guangzhou 510115， China
[Abstract] Objective To evaluate the efficacy of recombinant human interferon α-1b combined with bacterial lysates for the immune function of children with recurrent respiratory tract infection. Methods All 151 children with recurrent respiratory tract infection hospitalized and treated in our hospital from June 2013 to June 2014 were selected as the study subjects and 20 normal children were selected as the normal control group. All the children received recombinant human interferon α-1b combined with bacterial lysates treatment on the basis of conventional treatment. The flow cytometry and electrochemiluminescence were used to detect the changes in serum T cell levels and serum corticosterone （COR） contents of the sick children during illness and 4 weeks after respiratory symptom disappearance and of the healthy children. The differences in cell immune state and the changes of serum cortisol contents between the three types were compared. Results The serum T lymphocytes CD3 and CD4 and serum COR levels of the recovery group were significantly higher than those of the attack group， but the T lymphocyte CD8 level was significantly lower than that of the attack group， with statistically significant differences （P<0.05）. The T lymphocytes CD3 and CD4 and serum COR levels of the attack group were significantly lower than those of the normal control group， but the T lymphocyte CD8 level was significantly higher than that of the normal control group， with statistically significant difference （P<0.05）. Conclusion The immune function of children with recurrent respiratory tract infection is disorganized. Recombinant human interferon α-1b combined with bacterial lysates can regulate immune system， improve immune function and exert significant clinical effects， thereby worthy of wide promotion and application.