封闭综合征(locked-in syndrome,LIS)首由Plum等(1966)创用,表现为四肢瘫痪、哑症及较后的颅神经麻痹而意识清楚,交谈时有垂直眼球活动及眨眼。常见于脑桥广泛病变,如梗塞、肿瘤、中央性脑桥髓鞘破坏、多发性硬化症及颈椎按摩所致的椎动脉拉伤(dissection)。早年Duanas(1844)描述过类似表现,Darolles(1875)报告1例基底动脉梗塞而呈上述表现。 Lock-in syndrome (LIS), first used by Plum et al. (1966), is characterized by paralysis of the limbs, dumbness and subsequent cranial nerve palsy, with vertical eye movements and blinking during conversations. Common in a wide range of lesions of the pons, such as infarction, tumors, central pontine myelin sheath destruction, multiple sclerosis and cervical spondylosis caused by vertebral artery dissection. Duanas (1844) described a similar behavior in his early years, while Darolles (1875) reported one case of basilar artery infarction.