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肝癌是一种常见的恶性肿瘤,素有“癌中之王”之称。尽管肝癌标志物AFP检测的开展及影像学的发展使许多亚临床肝癌或小肝癌得以检出并行手术治疗,但大部分肝癌确诊时已属晚期且常常合并肝硬变。对这些病人,需采用包括手术在内的综合治疗,其中化疗,特别是局部灌注化疗占有重要地位。由于原发性肝癌对多种化疗方案的敏感性不超过20%,因此化疗效果仍不理想。近年人们认识到肿瘤细胞抗药性与细胞多药耐药(multidrug resistance, MDR)
Liver cancer is a common malignancy and is known as the “king of cancer.” Although the development of liver cancer markers AFP and the development of imaging have led to the detection of many subclinical liver cancers or small liver cancers in parallel, most of the liver cancers have been diagnosed late and often have cirrhosis. For these patients, comprehensive treatment including surgery is required. Chemotherapy, especially local infusion chemotherapy, plays an important role. Since the sensitivity of primary liver cancer to multiple chemotherapy regimens does not exceed 20%, the effect of chemotherapy is still not ideal. In recent years, it has been recognized that tumor cell resistance and multidrug resistance (MDR)