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目的 探讨耐利福平肺结核患者的临床治疗方法及其效果.方法 随机选取河南省胸科医院2010年7月至2013年9月期间收治的耐利福平肺结核患者60例,将其随机平均分配为试验组和对照组,其中试验组患者采用DEZTnT方案进行治疗,对照组患者采用DEZThP方案进行治疗,对比两组患者的痰菌阴转及肺结核病灶吸收情况.结果 治疗结束时,试验组患者痰菌阴转率明显高于对照组患者,肺结核病灶的总改善有效率明显高于对照组患者,差异具有统计学意义(P＜0.05);两组患者不良反应发生率对比差异未见统计学意义(P＞0.05).结论 采用利福喷汀治疗耐利福平肺结核患者,疗效显著,安全可靠,建议在临床上进一步推广应用.“,”Objective To investigate the effect of treatment for rifampin-resistant tuberculosis (TB) patients.Methods Sixty rifampin-resistant TB patients from July 2010 to September 2013 were selected and randomly assigned to the experimental group and the control group.The experimental group was treated with DEZTnT program and control patients treated with DEZThP program.Sputum seroconversion and absorption of pulmonary tuberculosis nidus of patients in the two groups were compared.Results Sputum seroconversion rate of the experimental group were significantly higher than that of control group.Tuberculosis nidus improvement in experimental group was also more significant than that of control group.The differences were all significant (P ＜ 0.05).The incidences of adverse reactions among two groups were not significantly different(P ＞ 0.05).Conclusions Rifapentine treatment for rifampicin-resistant TB patients is effective and reliable,this study therefore recommends it for further clinical practice.