随着对女性压力性尿失禁(SUI)发病机制的深入研究,其分子生物学机制受到高度重视,弹性纤维作为盆底支持组织细胞外基质的重要功能性成分,赋予组织重要的弹性功能,若其功能受影响将导致支持组织失去弹性,盆底松弛,盆底功能障碍性疾病相继发生。弹性蛋白酶特异性抑制物elafin基因在女性SUI患者的阴道组织中高表达,可能与盆底组织弹性纤维的重塑有内在联系,构成女性SUI的发病基础。 With the in-depth study of the pathogenesis of female stress urinary incontinence (SUI), its molecular biological mechanism has received great attention. As an important functional component of pelvic floor supporting tissue extracellular matrix, elastic fibers give the important elastic function of the tissue. If Its function will lead to support organizations lose their elasticity, pelvic floor relaxation, pelvic floor dysfunction disease have occurred. Elastase specific inhibitor elafin gene in female SUI patients with high expression of vaginal tissues may be remodeling of pelvic floor elastic fibers are intrinsically linked to the formation of female SUI basis.