论文部分内容阅读
目的分析报告湖南省1起家庭聚集性人感染H7N9禽流感疫情,为今后防控工作提供科学依据。方法按照《人感染H7N9禽流感诊疗方案(2014年版)》进行病例诊断,由疾病预防控制中心专业人员按照《人感染H7N9禽流感流行病学调查方案(2013年版)》进行调查,采用real-time PCR对病例和环境标本进行检测和病毒培养,并对分离出的病毒进行全基因组序列测定和分析。结果 2014年2月湖南双峰县发生一起人感染H7N9禽流感家庭聚集性疫情,报告病例2例,二者系夫妻关系;妻子为首发病例,发病前多日居住在有活禽活动的农村家中,发病后7d确诊;丈夫比妻子晚发病9d,与妻子密切接触,发生人传人的可能性大,发病后次日确诊;自丈夫标本中分离到H7N9亚型病毒,该病毒基因序列分析与既往报道病毒相似;从病例居家鸡舍表面和鸡毛涂抹标本各1份H7N9禽流感病毒核酸阳性,该县城主要集市活禽交易店3份环境标本H7N9禽流感病毒核酸阳性。结论两例病例系人感染H7N9禽流感家庭聚集性病例,首发病例系禽类暴露感染,续发病例系密切接触首发病例感染可能性大,H7N9禽流感病毒具有有限的人传人传播能力,对人感染H7N9禽流感病例的密切接触者实施医学观察很有必要。
Objective To analyze and report one outbreak of H7N9 bird flu in familial human in Hunan Province and provide scientific basis for future prevention and control. Methods The cases were diagnosed according to the Human Infection with H7N9 Bird Flu Program (2014 Edition) and were investigated by CDC professionals according to “Human Infection Epidemiology Survey of H7N9 Avian Influenza (2013 Edition)”. The real-time PCR detection of cases and environmental specimens and virus culture, and the isolated virus genome-wide sequence determination and analysis. Results In February 2014, a cluster of H9N9 domestic flocks were found in Shuangfeng County of Hunan Province. There were 2 reported cases of the relationship between husband and wife. The wife was the first case and lived in a rural household living with live poultry for a few days before onset , 7d after the onset of diagnosis; husband 9d later than his wife onset, in close contact with his wife, the possibility of human transmission is large, the day after the onset of diagnosis; H7N9 subtype virus isolated from her husband specimens, the virus sequence analysis of the virus and the past Reported a similar virus; from the case home chicken coop and chicken feces smear specimens of each of the H7N9 avian influenza virus nucleic acid positive, the county main market live poultry store three H7N9 bird flu positive for nucleic acid. Conclusions Two cases of human H7N9 influenza A (H7N9) co-infection were found in the first trimester of domestic flocks. The first case was exposed to poultry infection. Infection cases were closely associated with the first case infection. The H7N9 avian influenza virus had limited human-to-human transmission, Close contacts of H7N9 bird flu cases are in need of medical observation.