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肌肉蛋白质分解、能量代谢率的升高、糖代谢紊乱,和体重下降是创伤/感染病人的特征性的代谢反应。除激素或白细胞产生的内源性调节介质(Leukocyte endogenous mediator,LEM)作用外,营养基质摄入的减少和需要量的增加是导致上述反应的重要因素。有效地提供胃肠外途径的营养基质支持,有可能改善这种分解代谢的负氮平衡和热量平衡。由于创伤/感染所致的葡萄糖代谢的动力学改变,单纯以葡萄糖为能量来源的完全胃肠外营养(total parenteral nutrition,TPN)支持受到限制。国内对脂肪乳剂的 肌肉蛋白质分解、能量代谢率的升高、糖代谢紊乱,和体重下降是创伤/感染病人的特征性的代谢反应。除激素或白细胞产生的内源性调节介质(Leukocyte endogenous mediator,LEM)作用外,营养基质摄入的减少和需要量的增加是导致上述反应的重要因素。有效地提供胃肠外途径的营养基质支持,有可能改善这种分解代谢的负氮平衡和热量平衡。由于创伤/感染所致的葡萄糖代谢的动力学改变,单纯以葡萄糖为能量来源的完全胃肠外营养(total parenteral nutrition,TPN)支持受到限制。国内对脂肪乳剂的应用已有十多年历史,但对混合能源(即双能源)7PN支持的临床研究报告还很少。 人工胃肠(artificial gut)支持(即TPN支持)能否获得理想的效?
Muscle protein breakdown, increased energy metabolic rate, glucose metabolism disorders, and weight loss are characteristic metabolic reactions in trauma / infected patients. In addition to the hormonal or leukocyte producing endogenous mediator (LEM) effect, nutrient substrate intake reduction and increased demand are important factors that lead to the above reaction. Effectively providing nutritional substrate support for parenteral routes may improve the negative nitrogen balance and caloric balance of this catabolism. Total parenteral nutrition (TPN) support, which is purely glucose as a source of energy, is limited due to the kinetic changes in glucose metabolism caused by trauma / infections. Domestic domestic fat emulsion muscle protein breakdown, increased energy metabolic rate, glucose metabolism disorders, and weight loss is a traumatic / infectious patient’s characteristic metabolic response. In addition to the hormonal or leukocyte producing endogenous mediator (LEM) effect, nutrient substrate intake reduction and increased demand are important factors that lead to the above reaction. Effectively providing nutritional substrate support for parenteral routes may improve the negative nitrogen balance and caloric balance of this catabolism. Total parenteral nutrition (TPN) support, which is based solely on glucose, is limited due to the kinetic changes in glucose metabolism due to trauma / infection. The domestic application of fat emulsion has been more than ten years old, but there is still little report on the clinical research supported by 7PN of mixed energy (ie dual energy). Artificial gastrointestinal (artificial gut) support (ie TPN support) can achieve the desired effect?