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同步检测７６例窒息新生儿血浆ＥＴ－１、ＥＣＧ、血气分析、血清心肌酶、Ｃｒ、ＢＵＮ、β２－ＭＧ、尿β２－ＭＧ。结果表明：患儿血浆ＥＴ－１水平在ＥＣＧ示心肌受损者明显高于ＥＣＧ正常者，血气示呼吸衰竭者明显高于血气正常者（Ｐ＜０．００１）。患儿血清Ｃｒ、ＢＵＮ及β２－ＭＧ与血浆ＥＴ－１明显正相关（Ｐ＜０．０５）。在病情严重的患儿当中，死亡者血浆ＥＴ－１明显高于存活者（Ｐ＜０．０５）。提示ＥＴ－１与新生儿窒息后心、肺、肾功能受损有密切关系，拮抗ＥＴ－１的病理作用可能在治疗学上有一定意义。
The plasma levels of ET-1, ECG, blood gas analysis, serum myocardial enzymes, Cr, BUN, β2-MG and urinary β2-MG in 76 neonates with asphyxia were detected synchronously. The results showed that the plasma levels of ET-1 in children with myocardial infarction were significantly higher than those with normal ECG, and those with respiratory failure were significantly higher than those with normal blood gas (P <0.001). Children with serum Cr, BUN and β2-MG and plasma ET-1 was significantly correlated (P <0.05). Plasma ET-1 levels were significantly higher in survivors than in survivors (P <0.05). These results suggest that ET-1 is closely related to impaired cardiopulmonary, pulmonary and renal function after neonatal asphyxia. Antagonism of ET-1 may be of therapeutic significance.