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本文报道三尖杉酯碱(Harringtonine;HT)对10种人白血病淋巴瘤细胞系的生长抑制作用。结果表明,这些细胞系对HT 的敏感性差别很大。其中,HT 对HL-60细胞生长抑制作用最强,而对DND-41作用最弱,其敏感性差异相差70倍。这些细胞系对HT 的敏感性依下列次序递减:HL-60>RPMI-8402>DND-39A≌ML-2≌MOLT-3≌KG-1>Daudi≌NALL-1>BALM-2>DND-41。生长快的细胞系对HT 较
This article reports the inhibitory effect of Harringtonine (HT) on the growth of 10 human leukemia lymphoma cell lines. The results show that these cell lines on HT sensitivity vary greatly. Among them, HT had the strongest inhibitory effect on the growth of HL-60 cells and the weakest effect on DND-41, with a difference of 70-fold difference in sensitivity. The sensitivity of these cell lines to HT is decreasing in the following order: HL-60> RPMI-8402> DND-39A ≌ ML-2≌MOLT-3≌KG-1> Daudi≌NALL-1> BALM-2> DND-41 . Fast growing cell lines to HT