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用固相微萃取技术从血中提取芬氟拉明、苯丙胺和甲基苯丙胺。在 70℃条件下用 10 0 μm聚二甲基硅氧烷萃取头吸附 15min。重氢甲基苯丙胺作内标 ,采用柱前衍生化的进样方式 ,气质联用仪测定。选择离子m /z2 6 8(芬氟拉明 )、m/z2 40 (苯丙胺 )、m /z2 5 4(甲基苯丙胺 )和m/z2 5 8(重氢甲基苯丙胺 ,内标 )的峰面积比定量。血中检测浓度可达 0 0 1～ 0 0 3μg/g。通过解剖例中芬氟拉明的实际测定 ,证明这是一个从血液中提取分析苯丙胺类衍生物的快速准确的方法
Fenfluramine, amphetamine and methamphetamine were extracted from the blood by solid-phase microextraction. Adsorption was carried out with a 10 0 μm polydimethylsiloxane extraction head at 70 ° C for 15 min. DHMH as an internal standard, using pre-column derivatization of the injection mode, GC-MS. Peaks of ion m / z 268 (fenfluramine), m / z 2 40 (amphetamine), m / z 254 (methamphetamine) and m / z 258 (internal standard) Area ratio of quantitative. Detection of blood concentrations up to 0 0 1 ~ 0 0 3μg / g. The actual determination of fenfluramine in the dissection example proves to be a fast and accurate method for extracting and analyzing amphetamine derivatives from the blood