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目的探讨研究左甲状腺素钠治疗老年原发性甲状腺功能减退的临床效果及安全性。方法选取本院2010年9月-2011年5月采用左甲状腺素钠进行治疗的24例老年原发性甲状腺功能减退患者为观察组,同期采用甲状腺片进行治疗的24例患者为对照组,比较两组患者治疗后3个月及6个月的总有效率、不良反应发生率及不同严重程度者的总有效率。结果观察组治疗后3个月及6个月的总有效率明显高于对照组,不良反应发生率也低于对照组,不同严重程度者的总有效率也均高于对照组,差异均有统计学意义(P<0.05)。结论左甲状腺素钠在老年原发性甲状腺功能减退中的临床有效率较高,不良反应相对更低,综合效果较佳。
Objective To investigate the clinical efficacy and safety of levothyroxine in the treatment of senile primary hypothyroidism. Methods Twenty-four elderly patients with primary hypothyroidism who were treated with levothyroxine sodium from September 2010 to May 2011 in our hospital were selected as the observation group. Twenty-four patients treated with thyroid tablets during the same period were compared. The two groups of patients after 3 months and 6 months of total effective rate, the incidence of adverse reactions and different severity of the total effective rate. Results The total effective rate at 3 months and 6 months after treatment in observation group was significantly higher than that in control group, and the incidence of adverse reactions was also lower than that in control group. The total effective rate in different severity groups was also higher than that in control group Statistical significance (P <0.05). Conclusion The clinical efficacy of levothyroxine sodium in senile primary hypothyroidism is high, the adverse reactions are relatively lower, and the comprehensive effect is better.