缺氧 /复氧诱导细胞凋亡与其诱导细胞产生的复杂的生理反应 ,如线粒体细胞色素C释放、活性氧生成及线粒体Ca2 +向胞质转移等密切相关 ,这些生理异常均直接或间接地启动了细胞凋亡 ;缺氧 /复氧诱导细胞凋亡过程受Bcl 2家族蛋白、能量代谢、缺氧诱导因子以及缺氧反应基因等多因素的调控 Hypoxia / reoxygenation-induced apoptosis is closely related to the complex physiological responses induced by the cells, such as mitochondrial cytochrome C release, reactive oxygen species generation and mitochondrial Ca2 + to cytosolic transfer. All of these physiological abnormalities are directly or indirectly activated Apoptosis; Hypoxia / reoxygenation induction of apoptosis by the Bcl 2 family protein, energy metabolism, hypoxia inducible factor and hypoxia response genes and other factors