论文部分内容阅读
目的探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)在非小细胞肺癌患者侵袭和转移中的意义。方法非小细胞肺癌患者70例为肺癌组,体检健康者50例为对照组,采用ELISA法检测2组血清MMP-9水平并进行比较,比较肺癌组鳞癌与腺癌患者,有、无淋巴结转移者及对照组不同年龄间血清MMP-9水平。结果肺癌组血清MMP-9水平[(981.23±326.54)μg/L]明显高于对照组[(201.32±7.23)μg/L](P<0.05);肺癌组有淋巴结转移者血清MMP-9水平[(1 251.23±243.34)μg/L]明显高于无淋巴结转移者[(723.54±315.32)μg/L](P<0.05),鳞癌患者血清MMP-9水平[(898.97±249.67)μg/L]与腺癌患者[(1 024.25±214.22)μg/L]比较差异无统计学意义(P>0.05);对照组不同年龄间血清MMP-9水平比较差异均无统计学意义(P>0.05)。结论 MMP-9可作为临床判断肺癌侵袭和转移的生物学指标。
Objective To investigate the significance of matrix metalloproteinase-9 (MMP-9) in invasion and metastasis of non-small cell lung cancer patients. Methods Seventy patients with non-small cell lung cancer were selected as lung cancer group and 50 healthy control subjects as control group. Serum MMP-9 levels were measured by ELISA in two groups and compared between patients with squamous cell carcinoma and adenocarcinoma, with or without lymph node Metastasis and control groups at different ages serum MMP-9 levels. Results The level of serum MMP-9 in lung cancer group was significantly higher than that in control group [(981.23 ± 326.54) μg / L [(201.32 ± 7.23) μg / L] (P <0.05) The level of serum MMP-9 in patients with squamous cell carcinoma [((251 251 ± 243.34) μg / L] was significantly higher than that without lymph node metastasis [(723.54 ± 315.32) μg / L] L] and adenocarcinoma [(1 024.25 ± 214.22) μg / L] (P> 0.05). There was no significant difference in serum MMP-9 levels between control groups in different ages (P> 0.05 ). Conclusion MMP-9 can be used as a biological indicator for clinical diagnosis of lung cancer invasion and metastasis.