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据《Lancet》1999年353卷第9171期报道 动脉内膜切除术对某些颈动脉狭窄病人是有益的,但其受到围手术期危险性的制约。乙酰水杨酸则可降低有过一过性局部缺血发作和和风病人发生中风的危险性。为此,加拿大Mc-Master大学临床流行病学和生物统计学系D.W.Taylor教授等,对施行颈动脉内膜切除术病人的乙酰水杨酸合适剂量及其作用进行了探讨。在一项随机双盲对照试验中,对预计做颈动脉内膜切除的2849例病人,随机每天给予81mg(n=709),325 mg(n=708),650mg(n=715)或1300mg(n=717)乙酰水杨酸,于手术前开始并持续3个月。对中风、心肌梗死和死亡的发生情况作了登记,并对两个高剂
According to Lancet 1999 Vol. 353 No. 9171, endarterectomy is reported to be beneficial for some patients with carotid stenosis, but is limited by the perioperative risk. Acetylsalicylic acid can reduce the risk of having a transient ischemic attack and stroke patients with stroke. To this end, Canada Mc -Master University Department of Clinical Epidemiology and Biostatistics Professor D.W.Taylor, etc., the implementation of carotid endarterectomy patients acetylsalicylic acid dose and its effects were discussed. In a randomized double-blind controlled trial, 2849 patients enrolled for carotid endarterectomy were randomized to receive either 81 mg (n = 709), 325 mg (n = 708), 650 mg (n = 715) or 1300 mg n = 717) acetylsalicylic acid, beginning preoperatively and continuing for 3 months. The incidence of stroke, myocardial infarction and death was registered, and two high doses